Jean-Baptiste Grenouille came into the world unwanted, expected to die, yet born with an unnerving sense of smell that created alienation as well as talent. Of all the smells around him, Grenouille is beckoned to the scent of a woman's soul, and spends the rest of his life attempting to smell her essence again by becoming a perfumer, and creating the essence of an innocence lost.

Accused of killing his brother during adolescence, Salvador lives isolated in the middle of Patagonia. After several decades without seeing, his brother Marcos and his sister-in-law Laura, come to convince him to sell the lands that they share by inheritance. The crossing, in the middle of a lonely and inaccessible place, revives the duel where the roles of victim and murderer are transformed over and over again.

Two years after the murder of his son and father, a retired hitman sets in motion a carefully crafted revenge plan against the killer: his own brother.